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Nature. 1989 Nov 30;342(6249):498-505.

Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau.

Author information

1
Department of Biochemistry, NYU Medical Center, New York 10016.

Abstract

Here we report that the microtubule-associated proteins MAP2 and tau share two separable functional domains. One is the microtubule-binding site which serves to nucleate microtubule assembly; the second is a short C-terminal alpha-helical sequence which can crosslink microtubules by means of a hydrophobic zipper interaction into dense stable parallel arrays characteristic of axons or dendrites. Thus, interactions between molecules of a single type are capable of drastically reorganizing microtubules and completely suppressing their dynamic properties.

PMID:
2511449
DOI:
10.1038/342498a0
[Indexed for MEDLINE]

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