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Trends Immunol. 2014 Sep;35(9):408-19. doi: 10.1016/j.it.2014.07.005. Epub 2014 Aug 8.

Long non-coding RNAs in the regulation of the immune response.

Author information

1
Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
2
Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address: m.a.lindsay@bath.ac.uk.

Abstract

It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of lncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These lncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein-protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and lncRNA biology.

KEYWORDS:

adaptive immune response; antisense; innate immune response; lincRNA, inflammation; long noncoding RNA

PMID:
25113636
DOI:
10.1016/j.it.2014.07.005
[Indexed for MEDLINE]

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