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J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):525-31. doi: 10.1093/gerona/glu122. Epub 2014 Aug 11.

Vitamin D insufficiency and abnormal hemoglobin a1c in black and white older persons.

Author information

1
UCONN Center on Aging, Department of Medicine, University of Connecticut Health Center, Farmington. kositsawat@uchc.edu.
2
UCONN Center on Aging, Department of Medicine, University of Connecticut Health Center, Farmington.
3
Department of Biostatistical Sciences, Division of Public Health Sciences and.
4
Section on Gerontology & Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina.
5
Department of Epidemiology, Center for Aging and Population Health, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
6
Division of General Internal Medicine, University of California, San Francisco.
7
Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland.
8
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis.
9
UCONN Center on Aging, Department of Psychiatry, University of Connecticut Health Center, Farmington.

Abstract

BACKGROUND:

Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5%) in community-dwelling older persons and examined whether this relationship differed according to race.

METHODS:

Participants were 2,193 persons of age 70-79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested.

RESULTS:

A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03-2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95% CI: 1.00-5.40). Findings did not differ by race.

CONCLUSIONS:

Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.

KEYWORDS:

Hemoglobin A1c; Older persons.; Vitamin D

PMID:
25112493
PMCID:
PMC4375414
DOI:
10.1093/gerona/glu122
[Indexed for MEDLINE]
Free PMC Article
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