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Neuropathology. 2015 Feb;35(1):50-5. doi: 10.1111/neup.12142. Epub 2014 Aug 11.

Malignant transformation of craniopharyngioma with detailed follow-up.

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1
Department of Pathology, Guangzhou Liuhuaqiao Hospital, Guangzhou, China.

Abstract

A 29-year-old male patient was admitted into hospital with the main complaint of progressive visual disturbance. Both CT SCAN and MRI demonstrated a cystic-solid contrast-enhancing sellar-suprasellar mass with obvious calcification. Histopathological examination of the first resected specimen showed a typical appearance of adamantinomatous craniopharyngioma. The patient received gamma knife therapy after his first operation because of partial tumor removal. He experienced two relapses in the subsequent 2 years, for which only surgical resection was performed. The later histopathology presented malignant appearance with tumor cells moderate to severe pleomorphism, hyperchromasia, increased nuclear cytoplastic ratio, high mitotic activity (30/10 high power fields) and focal coagulative necrosis. The patient died 9 months after identification of histologic malignancy. Clinical and histopathological features, biological behavior of one case of malignant craniopharyngioma were discussed, with a brief review of the relevant literature.

KEYWORDS:

craniopharyngioma; follow-up; malignant transformation; prognosis; radiotherapy

PMID:
25112406
DOI:
10.1111/neup.12142
[Indexed for MEDLINE]
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