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J Womens Health (Larchmt). 2014 Aug;23(8):642-8. doi: 10.1089/jwh.2014.4770.

Risks and effectiveness of compounded bioidentical hormone therapy: a case series.

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1 Cleveland Clinic Lerner College of Medicine of Case Western University , Cleveland, Ohio.


After the publication of the Women's Health Initiative, attitudes towards management of menopausal symptoms changed dramatically. One alternative that has received much media attention is the use of bioidentical hormone therapy (BHT). The media and celebrity endorsements have promoted a number of misconceptions about the risks and benefits associated with the various forms of BHT. This article will review the available evidence regarding the safety and efficacy of BHT in comparison to conventional hormone therapy. We will also review several cases seen in our midlife women's referral clinics, which demonstrate concerns for the safety and efficacy of BHT, including unexplained endometrial cancer in otherwise healthy BHT users. Due to the lack of sufficient data to support the efficacy or safety of BHT, we recommend the use of United States Food and Drug Administration-approved regimens in the management of menopausal symptoms.

[Indexed for MEDLINE]

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