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Biochem Biophys Res Commun. 2014 Sep 5;451(4):516-21. doi: 10.1016/j.bbrc.2014.08.008. Epub 2014 Aug 9.

MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure.

Author information

1
Research Group Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Germany.
2
Department of Cardiac Surgery, Goethe University Frankfurt, Frankfurt, Germany.
3
Research Group Molecular Medicine, Department of Anesthesiology, University of Munich (LMU), Germany. Electronic address: simone.kreth@med.uni-muenchen.de.

Abstract

The myocardial endocannabinoid system has been linked to stress response and cardioprotection. In chronic heart failure (CHF), protective CB2 receptors are markedly up-regulated while CB1 receptors are slightly down-regulated. We here provide evidence that myocardial CB receptors are subject to microRNA regulation. By a combined computational and experimental approach we show that CB1 receptors are regulated by miR-494, and CB2 receptors are targeted by miR-665. Moreover, we demonstrate that in CHF, miR-665 expression is significantly decreased while miR-494 is slightly increased, which is concordant with the previously reported alterations of CB receptors. These results suggest that in CHF, altered expression of specific miRNAs may contribute to a compensatory response of the diseased myocardium.

KEYWORDS:

CB1; CB2; Endocannabinoid system; MicroRNA

PMID:
25111814
DOI:
10.1016/j.bbrc.2014.08.008
[Indexed for MEDLINE]
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