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Gynecol Endocrinol. 2014;30(12):872-6. doi: 10.3109/09513590.2014.943718. Epub 2014 Aug 11.

Rapid peptidomic profiling of peritoneal fluid by MALDI-TOF mass spectrometry for the identification of biomarkers of endometriosis.

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a Institute of Food Sciences, National Research Council (CNR) Avellino Italy.
b S-IN Soluzioni Informatiche Vicenza Italy.
c Department of Obstetrics and Gynaecology, Second University of Naples Naples Italy.
d Department of Experimental Medicine, Section of Hygiene, Occupational and Forensic Medicine - Second University of Naples Naples Italy.


Peptidomic profiling of peritoneal fluid by Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF-MS) may represent a promising, suitable, rapid method for early diagnosis and staging of endometriosis. In a case-control study, peritoneal fluid was collected from 23 patients affected by endometriosis (eight minimal/mild endometriosis and 15 moderate/severe endometriosis) and six "endometriosis free" women undergoing laparoscopy. MALDI-TOF mass spectra of the peptide fraction extracted from peritoneal fluid samples lead to identify biomarkers potentially suitable for discriminating between peritoneal fluid samples from women affected by minimal/mild endometriosis and those from women affected by moderate/severe endometriosis. Peptidomic analysis of peritoneal fluid samples may define putative peptide biomarkers suitable for staging endometriosis and improve our understanding of the pathogenesis of endometriosis.


Biomarkers; MALDI-TOF-MS; endometriosis; laparoscopy; peptidomics

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