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Dermatol Surg. 2014 Sep;40(9):1010-9. doi: 10.1097/01.DSS.0000452629.76339.2b.

Platelet-rich plasma for androgenetic alopecia: a pilot study.

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*Plastic Surgery and Regenerative Surgery Unit, IDI-IRCCS, Rome, Italy; †Second Clinical Dermatology Unit, IDI-IRCCS, Rome, Italy; ‡Hair Restoration Surgery, Greco Medical Group, Sarasota, Florida; §Health Services Research Unit, IDI-IRCCS, Rome, Italy.



Androgenetic alopecia is a common condition, with severe attendant psychosocial implications, and for which it is difficult to obtain a satisfactory degree of clinical improvement.


To explore the possible clinical benefit of injecting platelet-derived growth factors into the scalp of patients using a specific autologous blood concentrate.


Two injections of a leukocyte platelet-rich plasma (L-PRP) with the addition of concentrated plasmatic proteins were administered at baseline and after 3 months (single spin at baseline and double-spin centrifugation at 3 months). Macrophotographs were taken at baseline and after 6 months, and 2 independent evaluators rated them using Jaeschke rating of clinical change.


Sixty-four consecutive patients were enrolled. Some improvement was seen in all patients by 1 evaluator and in 62 by the other. The mean change in clinical rating was 3.2 (95% confidence interval [CI], 2.9-3.5) and 3.9 (95% CI, 3.5-4.3), and the proportion of patients reaching a clinically important difference was 40.6% and 54.7%, according to the 2 evaluators, respectively.


Our pilot study may provide preliminary evidence that this treatment may induce some degree of clinical advantage for male- and female-pattern baldness. This may warrant the design of randomized controlled clinical trials to formally test this procedure.

[Indexed for MEDLINE]

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