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Curr Obstet Gynecol Rep. 2013 Dec 1;2(4):218-225.

Fertility Preservation for Prepubertal Girls: Update and Current Challenges.

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Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps 279, Baltimore, MD 21287, USA.
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, 1650 Orleans St., CRB1, Room 254, Baltimore, MD 21231, USA.
Department of Gynecology and Obstetrics, Division of Reproductive Endocrinology, Johns Hopkins University School of Medicine, 10751 Falls Road, Suite #280, Lutherville, MD 20193, USA.


With increasing rates of diagnosis of childhood cancers and the evolution of more effective treatment options resulting in prolonged life spans, fertility preservation counseling is an integral component of the discussion at the time of diagnosis of childhood cancers. The primary fertility preservation option that exists for prepubertal girls is ovarian tissue cryopreservation. Although ovarian tissue cryopreservation is still considered to be experimental in nature, live births have resulted from orthotopic tissue transplantation. Fertility preservation should be offered to all prepubertal girls at high-risk for premature ovarian failure as a result of gonadotoxic treatment. Ethical and legal questions surrounding these issues must be considered as more and more pediatric patients pursue fertility preservation.


Cancer survivorship; Fertility preservation; Oncofertility; Ovarian tissue cryopreservation; Pediatric cancer

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