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Aging Dis. 2013 Nov 26;5(4):226-37. doi: 10.14336/AD.2014.0500226. eCollection 2014 Aug.

Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations.

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Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine.
Department of Orthopedic Surgery, National Center for Geriatrics and Gerontology.


Sarcopenia, an aging-induced generalized decrease in muscle mass, strength, and function, is known to affect elderly individuals by decreasing mobile function and increasing frailty and imbalance that lead to falls and fragile fractures. Sarcopenia is a known risk factor for osteoporotic fractures, infections, and early death in some specific situations. The number of patients with sarcopenia is estimated to increase to 500 million people in the year 2050. Sarcopenia is believed to be caused by multiple factors such as disuse, malnutrition, age-related cellular changes, apoptosis, and genetic predisposition; however, this remains to be determined. Various methods have been developed, but no safe or effective treatment has been found to date. This paper is a review on the association between sarcopenia and its related-fractures and their diagnoses and management methods to prevent fractures.


diagnosis; muscle mass; osteoporosis; pathogenesis; sarcopenia; sarcopenia-related fracture; treatment

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