Format

Send to

Choose Destination
Trends Genet. 2014 Sep;30(9):408-17. doi: 10.1016/j.tig.2014.07.002. Epub 2014 Aug 7.

mRNA transport meets membrane traffic.

Author information

1
Eberhard Karls Universität Tübingen, Interfaculty Institute of Biochemistry, Hoppe-Seyler-Strasse 4, 72076 Tübingen, Germany.
2
Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Structural Biology, 85764 Neuherberg, Germany.
3
Heinrich Heine University Düsseldorf, Institute for Microbiology, Cluster of Excellence on Plant Sciences, 40204 Düsseldorf, Germany.
4
Heinrich Heine University Düsseldorf, Institute for Microbiology, Cluster of Excellence on Plant Sciences, 40204 Düsseldorf, Germany. Electronic address: feldbrue@hhu.de.

Abstract

Active transport and local translation of mRNAs ensure the appropriate spatial organization of proteins within cells. Recent work has shown that this process is intricately connected to membrane trafficking. Here, we focus on new findings obtained in fungal model systems. Important highlights are that RNA-binding proteins recognize cargo mRNA synergistically and that mRNAs are co-transported with membranous compartments such as the endoplasmic reticulum (ER) and endosomes. We further discuss a novel concept of endosome-coupled translation that loads shuttling endosomes with septin cargo, a process important for correct septin filamentation. Interestingly, evidence is accumulating that RNA and membrane trafficking are also tightly interwoven in higher eukaryotes, suggesting that this phenomenon is a common theme and not an exception restricted to fungi.

KEYWORDS:

actin; endoplasmic reticulum; endosomes; mRNP; microtubule; septin

PMID:
25110341
DOI:
10.1016/j.tig.2014.07.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center