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Chem Biol Interact. 2014 Oct 5;222:77-86. doi: 10.1016/j.cbi.2014.07.013. Epub 2014 Aug 7.

Preparation and characterization of bionanoemulsions for improving and modulating the antioxidant efficacy of natural phenolic antioxidant curcumin.

Author information

1
Centre for Nano Sciences, Central University of Gujarat, Gandhinagar 382030, India; School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India. Electronic address: parthmalik1986@gmail.com.
2
School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India. Electronic address: ametarakesh40@gmail.com.
3
Centre for Nano Sciences, Central University of Gujarat, Gandhinagar 382030, India; School of Chemical Sciences, Central University of Gujarat, Gandhinagar 382030, India. Electronic address: mansingh50@hotmail.com.

Abstract

An attempt to augment the antioxidant ability of curcumin, a natural phenolic compound via encapsulation in nontoxic nanoemulsions, has been made. Ethanol and glycerol catalyzed curcumin encapsulated nanoemulsions using cottonseed oil with mild cationic, anionic and nonionic surfactants have been prepared. The prepared bionanoemulsions were found to possess characteristic particle diameter between 100 and 900nm. The curcumin encased bionanoemulsions have been further screened for antioxidant efficacy with free radical 2, 2-diphenyl-1-picrylhydrazyl that enabled a radical scavenging activity of more than 90% as compared to pure curcumin. Alongside, the reduced surface tension and increased viscosity of curcumin encapsulated bionanoemulsions within 38.37-52.85mN/m and 0.7947-1.042mPa-s have quantitatively verified curcumin dispersion and interaction within the continuous medium, enabled via thermodynamic shift.

KEYWORDS:

Bioactive; Bionanoemulsions; Curcumin; Immunomodulatory; Surfactants

PMID:
25110318
DOI:
10.1016/j.cbi.2014.07.013
[Indexed for MEDLINE]

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