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Pathol Biol (Paris). 2014 Oct;62(5):252-61. doi: 10.1016/j.patbio.2014.05.014. Epub 2014 Aug 7.

Sleep and wake disturbances following traumatic brain injury.

Author information

1
Center for advanced research in sleep medicine, hôpital du Sacré-Coeur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec, H4J 1C5, Canada.
2
Center for advanced research in sleep medicine, hôpital du Sacré-Coeur de Montréal, 5400, boulevard Gouin Ouest, Montréal, Québec, H4J 1C5, Canada; Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, Québec, Canada. Electronic address: nadia.gosselin@umontreal.ca.

Abstract

Traumatic brain injury (TBI) is a major health concern in industrialised countries. Sleep and wake disturbances are among the most persistent and disabling sequelae after TBI. Yet, despite the widespread complaints of post-TBI sleep and wake disturbances, studies on their etiology, pathophysiology, and treatments remain inconclusive. This narrative review aims to summarise the current state of knowledge regarding the nature of sleep and wake disturbances following TBI, both subjective and objective, spanning all levels of severity and phases post-injury. A second goal is to outline the various causes of post-TBI sleep-wake disturbances. Globally, although sleep-wake complaints are reported in all studies and across all levels of severity, consensus regarding the objective nature of these disturbances is not unanimous and varies widely across studies. In order to optimise recovery in TBI survivors, further studies are required to shed light on the complexity and heterogeneity of post-TBI sleep and wake disturbances, and to fully grasp the best timing and approach for intervention.

KEYWORDS:

Circadian rhythms; Hypersomnia; Hypersomnie; Insomnia; Insomnie; Rythmes circadiens; Sleep; Sleep-wake disturbances; Sommeil; Traumatic brain injury; Traumatisme craniocérébral; Troubles du sommeil et de l’éveil

PMID:
25110283
DOI:
10.1016/j.patbio.2014.05.014
[Indexed for MEDLINE]

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