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Stem Cell Res. 2014 Nov;13(3 Pt B):556-70. doi: 10.1016/j.scr.2014.06.003. Epub 2014 Jul 9.

A neonatal blueprint for cardiac regeneration.

Author information

1
School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia.
2
Department of Molecular Biology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: eric.olson@utsouthwestern.edu.

Abstract

Adult mammals undergo minimal regeneration following cardiac injury, which severely compromises cardiac function and contributes to the ongoing burden of heart failure. In contrast, the mammalian heart retains a transient capacity for cardiac regeneration during fetal and early neonatal life. Recent studies have established the importance of several evolutionarily conserved mechanisms for heart regeneration in lower vertebrates and neonatal mammals including induction of cardiomyocyte proliferation, epicardial cell activation, angiogenesis, extracellular matrix deposition and immune cell infiltration. In this review, we provide an up-to-date account of the molecular and cellular basis for cardiac regeneration in lower vertebrates and neonatal mammals. The historical context for these recent findings and their ramifications for the future development of cardiac regenerative therapies are also discussed.

PMID:
25108892
PMCID:
PMC4316722
DOI:
10.1016/j.scr.2014.06.003
[Indexed for MEDLINE]
Free PMC Article
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