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Cell Rep. 2014 Aug 21;8(4):1105-18. doi: 10.1016/j.celrep.2014.06.042. Epub 2014 Aug 6.

Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems.

Author information

1
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA.
2
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: jeremiah.cohen@jhmi.edu.
3
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: mitsuko@mcb.harvard.edu.

Abstract

Serotonin and dopamine are major neuromodulators. Here, we used a modified rabies virus to identify monosynaptic inputs to serotonin neurons in the dorsal and median raphe (DR and MR). We found that inputs to DR and MR serotonin neurons are spatially shifted in the forebrain, and MR serotonin neurons receive inputs from more medial structures. Then, we compared these data with inputs to dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). We found that DR serotonin neurons receive inputs from a remarkably similar set of areas as VTA dopamine neurons apart from the striatum, which preferentially targets dopamine neurons. Our results suggest three major input streams: a medial stream regulates MR serotonin neurons, an intermediate stream regulates DR serotonin and VTA dopamine neurons, and a lateral stream regulates SNc dopamine neurons. These results provide fundamental organizational principles of afferent control for serotonin and dopamine.

PMID:
25108805
PMCID:
PMC4142108
DOI:
10.1016/j.celrep.2014.06.042
[Indexed for MEDLINE]
Free PMC Article

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