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Clin Nutr. 2015 Aug;34(4):775-8. doi: 10.1016/j.clnu.2014.07.002. Epub 2014 Jul 25.

Baseline oxidative defense and survival after 5-7 years among elderly stroke patients at nutritional risk: Follow-up of a randomized, nutritional intervention trial.

Author information

1
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway. Electronic address: poiversen@hotmail.com.
2
Atlantis Medical University College, Oslo, Norway.
3
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; Department of Clinical Service, Division of Cancer Medicine Surgery and Transplantation, Oslo University Hospital, Oslo, Norway.
4
Department of Gastroenterology, Oslo University Hospital, Ullevaal, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway.
5
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway; Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Norway.

Abstract

BACKGROUND & AIMS:

Patients at nutritional risk are particularly vulnerable to adverse outcomes of acute stroke. We previously found that increased energy- and protein intervention improved short-term survival among stroke patients with the highest baseline antioxidant capacity. We now examined survival of these patients after 5-7 years.

METHODS:

We studied 165 patients >65 years admitted to hospital for acute stroke and enrolled in a randomized nutritional intervention study in 2005-2007. Cox regression analysis was used to estimate the associations between all-cause mortality (through 2011) and baseline plasma levels of antioxidant markers (glutathione reducing capacity, alpha-tocopherol, vitamin C and total carotenoids).

RESULTS:

We found no significant difference (P = 0.86) in survival between the intervention and control group. Among the tested antioxidant markers, plasma levels above the median for total carotenoids were associated with reduced risk of death in the intervention group (adjusted hazard ratio, 0.29; 95% confidence interval, 0.12-0.71).

CONCLUSIONS:

Hospitalized patients that received enhanced dietary energy- and protein after acute stroke and with baseline plasma total carotenoids above median level, had reduced risk of death after 5-7 years. Further trials testing intervention with diets rich in antioxidants are warranted.

KEYWORDS:

Antioxidants; Elderly; Nutrition; Stroke; Survival

PMID:
25108573
DOI:
10.1016/j.clnu.2014.07.002
[Indexed for MEDLINE]

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