Format

Send to

Choose Destination
Clin Chim Acta. 2015 Jan 1;438:62-6. doi: 10.1016/j.cca.2014.07.042. Epub 2014 Aug 6.

Association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal Korean women.

Author information

1
Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; Institute of Women's Life Medical Science, Seoul, Republic of Korea.
2
Institute of Women's Life Medical Science, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
3
Institute of Women's Life Medical Science, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: dr222@yuhs.ac.

Abstract

BACKGROUND:

Several studies have suggested that increased iron storage may promote the development of atherosclerotic coronary heart disease. In the present study, we aimed to investigate the association of serum ferritin levels with metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women.

METHODS:

We examined 280 postmenopausal women who visited the health promotion center of our hospital for a routine health checkup. Metabolic syndrome was diagnosed by using the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III. The presence of coronary atherosclerosis was indicated by 64-row multi-detector computed tomography.

RESULTS:

The proportion of postmenopausal women with metabolic syndrome and coronary atherosclerosis in the highest ferritin quartile was significantly higher compared with that in the lowest quartile. Serum ferritin levels were independently associated with the presence of metabolic syndrome (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.313; 95% confidence interval, 1.251-8.775) and coronary atherosclerosis (adjusted odds ratio for the highest quartile versus the lowest quartile, 3.047; 95% confidence interval, 1.026-9.051), after adjusting for confounding factors.

CONCLUSIONS:

Elevated serum ferritin levels may be associated with an increased risk of metabolic syndrome and subclinical coronary atherosclerosis in postmenopausal women.

KEYWORDS:

Coronary atherosclerosis; Ferritin; Menopause; Metabolic syndrome

PMID:
25108208
DOI:
10.1016/j.cca.2014.07.042
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center