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Ageing Res Rev. 2014 Nov;18:41-52. doi: 10.1016/j.arr.2014.07.003. Epub 2014 Aug 11.

Cognitive impairment and cardiovascular diseases in the elderly. A heart-brain continuum hypothesis.

Author information

1
Department of Translational Medical Sciences, University of Naples "Federico II", Italy. Electronic address: p.abete@unina.it.
2
Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; IRCCS San Raffaele Pisana, Rome, Italy.
3
Division of Geriatrics, AON SS, Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
4
Department of Translational Medical Sciences, University of Naples "Federico II", Italy.
5
Division of Geriatrics, Ospedale "S. Maria di Ca' Foncello", Treviso, Italy.
6
Salvatore Maugeri Foundation, Institute of Veruno, Novara, Italy.
7
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
8
Department of Translational Medical Sciences, University of Naples "Federico II", Italy; Salvatore Maugeri Foundation, Institute of Campoli/Telese, Benevento, Italy.

Abstract

The aging population is increasing and, therefore, a higher prevalence of cardiac disease is emerging; including hypertension, coronary artery disease, atrial fibrillation and chronic heart failure. Large cohort studies have revealed a relationship among increased risk for cognitive impairment and dementia in cardiovascular diseases probably due to embolic stroke or chronic cerebral hypoperfusion. Thus, the aim of the present review is to overview the studies that investigate the presence and/or the development of cognitive impairments and dementia in patients with varied types of cardiovascular disease. Finally, a continuum among hypertension, coronary artery disease, atrial fibrillation and chronic heart failure with to the development of cognitive impairment and progression to dementia has been hypothesized.

KEYWORDS:

Cardiovascular disease; Cognitive impairment; Dementia

PMID:
25107566
DOI:
10.1016/j.arr.2014.07.003
[Indexed for MEDLINE]
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