Format

Send to

Choose Destination
Clin Infect Dis. 2014 Nov 1;59(9):1277-80. doi: 10.1093/cid/ciu642. Epub 2014 Aug 8.

Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions.

Author information

1
Division of Infectious Diseases, Department of Internal Medicine Division of Infectious Diseases, Department of Medicine, Clinica Alemana de Santiago, Universidad del Desarrollo, Chile.
2
Geffen School of Medicine at University of California at Los Angeles Los Angeles Biomedical Research Institute, Torrance, California.
3
Geffen School of Medicine at University of California at Los Angeles.
4
Division of Infectious Diseases, Department of Internal Medicine.
5
Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogotá, Colombia.
6
Division of Infectious Diseases, Department of Internal Medicine Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogotá, Colombia.
7
Division of Infectious Diseases, Department of Internal Medicine Department of Microbiology and Molecular Genetics, University of Texas Medical School.
8
Division of Infectious Diseases, Department of Medicine, MD Anderson Cancer Center, Houston.
9
Division of Infectious Diseases, Department of Internal Medicine Department of Microbiology and Molecular Genetics, University of Texas Medical School Molecular Genetics and Antimicrobial Resistance Unit, Universidad El Bosque, Bogotá, Colombia.

Abstract

High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 µg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations >2 µg/mL.

KEYWORDS:

Enterococcus faecium; daptomycin; resistance; treatment failure

PMID:
25107294
PMCID:
PMC4271039
DOI:
10.1093/cid/ciu642
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center