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Nucleic Acids Res. 2015 Jan;43(Database issue):D940-5. doi: 10.1093/nar/gku724. Epub 2014 Aug 8.

NutriChem: a systems chemical biology resource to explore the medicinal value of plant-based foods.

Author information

1
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, DK-2800 Lyngby, Denmark.
2
School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong.
3
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, DK-2800 Lyngby, Denmark irene@cbs.dtu.dk.

Abstract

There is rising evidence of an inverse association between chronic diseases and diets characterized by rich fruit and vegetable consumption. Dietary components may act directly or indirectly on the human genome and modulate multiple processes involved in disease risk and disease progression. However, there is currently no exhaustive resource on the health benefits associated to specific dietary interventions, or a resource covering the broad molecular content of food. Here we present the first release of NutriChem, available at http://cbs.dtu.dk/services/NutriChem-1.0, a database generated by text mining of 21 million MEDLINE abstracts for information that links plant-based foods with their small molecule components and human disease phenotypes. NutriChem contains text-mined data for 18478 pairs of 1772 plant-based foods and 7898 phytochemicals, and 6242 pairs of 1066 plant-based foods and 751 diseases. In addition, it includes predicted associations for 548 phytochemicals and 252 diseases. To the best of our knowledge this database is the only resource linking the chemical space of plant-based foods with human disease phenotypes and provides a foundation for understanding mechanistically the consequences of eating behaviors on health.

PMID:
25106869
PMCID:
PMC4383999
DOI:
10.1093/nar/gku724
[Indexed for MEDLINE]
Free PMC Article

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