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Nat Commun. 2014 Aug 8;5:4613. doi: 10.1038/ncomms5613.

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

Author information

1
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
2
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8581, Japan.
3
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
4
Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
5
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
6
1] Department of Epidemiology, Harvard School of Public Health, and the Channing Division of Network Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Dana-Farber/Harvard Cancer Center, Boston, Massachusetts 02115, USA.
7
1] Division of Epidemiology, Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37235, USA [2] International Epidemiology Institute, Rockville, Maryland 20850, USA.
8
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
9
Department of Gastroenterolgy-Research, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
10
Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire 03755, USA.
11
Cancer Prevention Institute of California, Fremont, California 94538, USA.
12
Service de Génétique Médicale, CHU Nantes, 44093 Nantes, France.
13
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
14
Division of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1J8M5.
15
Cancer Care Ontario, Toronto, Ontario, Canada M5G 2L3.

Abstract

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.

PMID:
25105248
PMCID:
PMC4180879
DOI:
10.1038/ncomms5613
[Indexed for MEDLINE]
Free PMC Article

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