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Bioessays. 2014 Oct;36(10):940-9. doi: 10.1002/bies.201400071. Epub 2014 Aug 8.

Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms.

Author information

1
Department of Emergency Medicine, University of New Mexico, Albuquerque, NM, USA.

Abstract

Microbes in the gastrointestinal tract are under selective pressure to manipulate host eating behavior to increase their fitness, sometimes at the expense of host fitness. Microbes may do this through two potential strategies: (i) generating cravings for foods that they specialize on or foods that suppress their competitors, or (ii) inducing dysphoria until we eat foods that enhance their fitness. We review several potential mechanisms for microbial control over eating behavior including microbial influence on reward and satiety pathways, production of toxins that alter mood, changes to receptors including taste receptors, and hijacking of the vagus nerve, the neural axis between the gut and the brain. We also review the evidence for alternative explanations for cravings and unhealthy eating behavior. Because microbiota are easily manipulatable by prebiotics, probiotics, antibiotics, fecal transplants, and dietary changes, altering our microbiota offers a tractable approach to otherwise intractable problems of obesity and unhealthy eating.

KEYWORDS:

cravings; evolutionary conflict; host manipulation; microbiome; microbiota; obesity

Comment in

PMID:
25103109
PMCID:
PMC4270213
DOI:
10.1002/bies.201400071
[Indexed for MEDLINE]
Free PMC Article

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