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Front Neuroendocrinol. 2015 Jan;36:49-71. doi: 10.1016/j.yfrne.2014.07.001. Epub 2014 Aug 4.

Species, sex and individual differences in the vasotocin/vasopressin system: relationship to neurochemical signaling in the social behavior neural network.

Author information

1
Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA 30302, USA. Electronic address: biohea@gsu.edu.

Abstract

Arginine-vasotocin (AVT)/arginine vasopressin (AVP) are members of the AVP/oxytocin (OT) superfamily of peptides that are involved in the regulation of social behavior, social cognition and emotion. Comparative studies have revealed that AVT/AVP and their receptors are found throughout the "social behavior neural network (SBNN)" and display the properties expected from a signaling system that controls social behavior (i.e., species, sex and individual differences and modulation by gonadal hormones and social factors). Neurochemical signaling within the SBNN likely involves a complex combination of synaptic mechanisms that co-release multiple chemical signals (e.g., classical neurotransmitters and AVT/AVP as well as other peptides) and non-synaptic mechanisms (i.e., volume transmission). Crosstalk between AVP/OT peptides and receptors within the SBNN is likely. A better understanding of the functional properties of neurochemical signaling in the SBNN will allow for a more refined examination of the relationships between this peptide system and species, sex and individual differences in sociality.

KEYWORDS:

Affiliation; Aggression; Communication; Estradiol; Oxytocin; Pair bonding; Sociality; Testosterone; V1a; V1b

PMID:
25102443
PMCID:
PMC4317378
DOI:
10.1016/j.yfrne.2014.07.001
[Indexed for MEDLINE]
Free PMC Article
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