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J Perinatol. 2015 Jan;35(1):39-45. doi: 10.1038/jp.2014.146. Epub 2014 Aug 7.

Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants.

Author information

1
Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
2
Gulhane Military Medical Faculty, Department of Neonatology, Istanbul, Turkey.
3
Gulhane Military Medical Faculty, Department of Biochemistry, Istanbul, Turkey.

Abstract

OBJECTIVE:

To evaluate the effect of vitamin D levels on early-onset sepsis (EOS) in term infants.

STUDY DESIGN:

Fifty term infants with clinical and laboratory findings of EOS (study group) and 50 healthy infants with no signs of clinical/laboratory infection (control group) were enrolled. Blood was drawn at the time of admission during the first 3 postnatal days of life in both groups for measurement of 25-hydroxyvitamin D (25-OHD) levels.

RESULT:

Maternal and neonatal 25-OHD levels (22.2/8.6 ng ml(-1), respectively) in the study group were significantly lower than those of the control group (36.2/19 ng ml(-1), respectively, P<0.001). A positive correlation was detected between maternal and neonatal 25-OHD levels. Severe vitamin D deficiency was significantly more common in the sepsis group.

CONCLUSION:

Lower maternal and neonatal 25-OHD levels are associated with EOS. These data suggest that adequate vitamin D supplementation during pregnancy may be helpful to prevent EOS in term neonates.

PMID:
25102323
DOI:
10.1038/jp.2014.146
[Indexed for MEDLINE]

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