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Virulence. 2014 Aug 15;5(6):655-64. doi: 10.4161/viru.32180. Epub 2014 Aug 7.

The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.

Author information

1
Research and Develop Center of New Drug; School of Pharmacy; Second Military Medical University; Shanghai, PR China.
2
Department of Pharmacology; School of Pharmacy; China Pharmaceutical University; Nanjing, PR China.

Abstract

Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively studied in the model yeast Saccharomyces cerevisiae. LTR-retrotransposons carry two LTRs flanking a long internal protein-coding domain, open reading frames. LTR-retrotransposons use RNA as intermediate to synthesize double-stranded DNA copies. In this article, we describe the structure feature, retrotransposition mechanism and the influence on organism diversity of LTR retrotransposons in C. albicans. We also discuss the relationship between pathogenicity and LTR retrotransposons in C. albicans.

KEYWORDS:

Candida albicans; LTR-retrotransposons; Tca; retrotransposition mechanism; structure feature

PMID:
25101670
PMCID:
PMC4139406
DOI:
10.4161/viru.32180
[Indexed for MEDLINE]
Free PMC Article

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