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Nat Med. 2014 Aug;20(8):847-56. doi: 10.1038/nm.3643.

Emerging interactions between skin stem cells and their niches.

Author information

1
1] Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, New York, USA. [2].
2
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, New York, USA.

Abstract

The skin protects mammals from insults, infection and dehydration and enables thermoregulation and sensory perception. Various skin-resident cells carry out these diverse functions. Constant turnover of cells and healing upon injury necessitate multiple reservoirs of stem cells. Thus, the skin provides a model for studying interactions between stem cells and their microenvironments, or niches. Advances in genetic and imaging tools have brought new findings about the lineage relationships between skin stem cells and their progeny and about the mutual influences between skin stem cells and their niches. Such knowledge may offer novel avenues for therapeutics and regenerative medicine.

PMID:
25100530
PMCID:
PMC4358898
DOI:
10.1038/nm.3643
[Indexed for MEDLINE]
Free PMC Article

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