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Nat Med. 2014 Aug;20(8):808-9. doi: 10.1038/nm.3657.

A new activity for SAMHD1 in HIV restriction.

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1
Gladstone Institute of Virology and Immunology and the University of California-San Francisco, San Francisco, California, USA.

Abstract

Restriction factors are host cell proteins that inhibit retroviral infection. A new study using mutants of human HIV-1 restriction factor SAMHD1 suggests that it inhibits infection through degradation of viral RNA rather than through its dNTPase activity as previously suggested.

PMID:
25100520
DOI:
10.1038/nm.3657
[Indexed for MEDLINE]
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