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Structure. 2014 Aug 5;22(8):1071-1073. doi: 10.1016/j.str.2014.07.004.

Polo-like kinase 4 shapes up.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aholland@jhmi.edu.

Abstract

Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole targeting of the kinase.

PMID:
25099950
DOI:
10.1016/j.str.2014.07.004
[Indexed for MEDLINE]
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