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Nat Commun. 2014 Aug 6;5:4593. doi: 10.1038/ncomms5593.

Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity.

Author information

1
1] Institute of Immunology, University of Münster, 48149 Münster, Germany [2] Interdisciplinary Centre for Clinical Research, University of Münster, 48149 Münster, Germany [3].
2
1] Division of Imaging Sciences and Biomedical Engineering, King's College London, London SE1 7EH, UK [2] Department of Clinical Radiology, University of Münster, 48149 Münster, Germany [3].
3
Institute of Immunology, University of Münster, 48149 Münster, Germany.
4
1] Interdisciplinary Centre for Clinical Research, University of Münster, 48149 Münster, Germany [2] European Institute for Molecular Imaging, University of Münster, 48149 Münster, Germany.
5
Department of Rheumatology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
6
European Institute for Molecular Imaging, University of Münster, 48149 Münster, Germany.
7
1] Interdisciplinary Centre for Clinical Research, University of Münster, 48149 Münster, Germany [2] Department of Clinical Radiology, University of Münster, 48149 Münster, Germany.
8
1] Institute of Immunology, University of Münster, 48149 Münster, Germany [2] Interdisciplinary Centre for Clinical Research, University of Münster, 48149 Münster, Germany.
9
1] European Institute for Molecular Imaging, University of Münster, 48149 Münster, Germany [2] Cluster of Excellence EXC 1003 'Cells in Motion - CiM', University of Münster, 48149 Münster, Germany.
10
1] Interdisciplinary Centre for Clinical Research, University of Münster, 48149 Münster, Germany [2] Department of Radiology, St Franziskus Hospital Münster, 48145 Münster, Germany.
11
1] Institute of Immunology, University of Münster, 48149 Münster, Germany [2] Interdisciplinary Centre for Clinical Research, University of Münster, 48149 Münster, Germany [3] Cluster of Excellence EXC 1003 'Cells in Motion - CiM', University of Münster, 48149 Münster, Germany.

Abstract

Inflammation has a key role in the pathogenesis of various human diseases. The early detection, localization and monitoring of inflammation are crucial for tailoring individual therapies. However, reliable biomarkers to detect local inflammatory activities and to predict disease outcome are still missing. Alarmins, which are locally released during cellular stress, are early amplifiers of inflammation. Here, using optical molecular imaging, we demonstrate that the alarmin S100A8/S100A9 serves as a sensitive local and systemic marker for the detection of even sub-clinical disease activity in inflammatory and immunological processes like irritative and allergic contact dermatitis. In a model of collagen-induced arthritis, we use S100A8/S100A9 imaging to predict the development of disease activity. Furthermore, S100A8/S100A9 can act as a very early and sensitive biomarker in experimental leishmaniasis for phagocyte activation linked to an effective Th1-response. In conclusion, the alarmin S100A8/S100A9 is a valuable and sensitive molecular target for novel imaging approaches to monitor clinically relevant inflammatory disorders on a molecular level.

PMID:
25098555
PMCID:
PMC4143994
DOI:
10.1038/ncomms5593
[Indexed for MEDLINE]
Free PMC Article

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