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Med Sci Monit. 2014 Aug 6;20:1383-8. doi: 10.12659/MSM.890731.

Assessment of cardiac functions in infants with cow's milk allergy.

Author information

  • 1Department of Pediatric Cardiology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
  • 2Department of Pediatric Gastroenterology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
  • 3Department of Pediatrics, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.
  • 4Department of Pediatric Cardiology, Balıkesir Atatürk Hospital, Balıkesir, Turkey.



Cow's milk allergy is the most common food allergy in children, with rates estimated at 1.9% to 4.9%. Clinical phenotypes of cow's milk allergy are varied and involve 1 or more target organs, with the main targets being the skin, respiratory system, and gastrointestinal tract. To date, no studies have investigated detailed cardiac function in children with cow's milk allergy. The current study aimed to investigate cardiac function in infants with cow's milk allergy.


We studied 42 infants with cow's milk allergy and 30 age- and sex-matched healthy subjects. Cardiac functions were evaluated by M-mode, pulsed-wave, and tissue Doppler echocardiography.


There were no significant differences in ejection fraction or mitral and tricuspid annular plane systolic excursion between the 2 groups. Pulsed-wave Doppler-derived E/A ratios in mitral and tricuspid valves were similar in both groups. Ea/Aa ratios in the left ventricle posterior wall and right ventricle free wall were lower in patients with cow's milk allergy than in the control group. The E/Ea ratio in the left ventricle, isovolumic relaxation time, deceleration time, and right and left ventricular myocardial performance indices were higher in patients in the study group.


Our study identified reduced early diastolic tissue Doppler velocities in infants with cow's milk allergy.

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