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Expert Rev Clin Immunol. 2014 Sep;10(9):1165-70. doi: 10.1586/1744666X.2014.942289. Epub 2014 Aug 7.

An update on leptin as immunomodulator.

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SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), the NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, Santiago de Compostela, Spain.


Until the discovery of leptin 20 years ago, adipose tissue was considered only as a fat storage organ, involved in the regulation of energy homeostasis. At present, it is well known that adipokines, being leptin the forerunner of this superfamily, may act in different biological processes, including inflammation and immunity. In this review, we have explored the recent evidence about the relationship between leptin and immune system, summarizing the most important findings related to the involvement of leptin in both innate and adaptive immune response.


T regulatory cell; Th1; Th2; adipokines; innate and adaptive immunity; leptin; macrophages; monocytes

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