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Nat Rev Cancer. 2014 Sep;14(9):632-41. doi: 10.1038/nrc3789. Epub 2014 Aug 7.

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression.

Author information

1
1] Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA. [2].
2
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.

Abstract

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However, during tumour progression and metastasis, cancerous epithelial cells must adapt to and survive in the absence of ECM. During the past 20 years, several cellular changes, including anoikis, have been shown to regulate cell viability when cells become detached from the ECM. In this Opinion article, we review in detail how cancer cells can overcome or take advantage of these specific processes. Gaining a better understanding of how cancer cells survive during detachment from the ECM will be instrumental in designing chemotherapeutic strategies that aim to eliminate ECM-detached metastatic cells.

PMID:
25098270
DOI:
10.1038/nrc3789
[Indexed for MEDLINE]

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