Format

Send to

Choose Destination
See comment in PubMed Commons below
Interface Focus. 2014 Aug 6;4(4):20140028. doi: 10.1098/rsfs.2014.0028.

Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment.

Author information

1
Princeton Institute for the Science and Technology of Materials (PRISM) , Princeton, NJ 08544 , USA ; Department of Electrical Engineering , Princeton University , Princeton, NJ 08544 , USA.
2
Department of Pathology , University of California at San Francisco , CA 94143 , USA.
3
Princeton Institute for the Science and Technology of Materials (PRISM) , Princeton, NJ 08544 , USA ; Department of Physics , Princeton University , Princeton, NJ 08544 , USA.

Abstract

Preventing relapse is the major challenge to effective therapy in cancer. Within the tumour, stromal (ST) cells play an important role in cancer progression and the emergence of drug resistance. During cancer treatment, the fitness of cancer cells can be enhanced by ST cells because their molecular signalling interaction delays the drug-induced apoptosis of cancer cells. On the other hand, competition among cancer and ST cells for space or resources should not be ignored. We explore the population dynamics of multiple myeloma (MM) versus bone marrow ST cells by using an experimental microecology that we call the death galaxy, with a stable drug gradient and connected microhabitats. Evolutionary game theory is a quantitative way to capture the frequency-dependent nature of interactive populations. Therefore, we use evolutionary game theory to model the populations in the death galaxy with the gradients of pay-offs and successfully predict the future densities of MM and ST cells. We discuss the possible clinical use of such analysis for predicting cancer progression.

KEYWORDS:

cancer; chemotherapy resistance; game theory; population dynamics; spatial heterogeneity; stroma

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center