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BMC Womens Health. 2014 Aug 5;14:93. doi: 10.1186/1472-6874-14-93.

Effect of metformin on serum interleukin-6 levels in polycystic ovary syndrome: a systematic review.

Author information

1
Department of Gynecology and Obstetrics, Liaocheng People's Hospital, 67 Dongchangxi Road, Liaocheng, Shandong Province 252000, China. xuxinghua523@gmail.com.

Abstract

BACKGROUND:

Most women with polycystic ovary syndrome (PCOS) have insulin resistance, hyperinsulinemia, and elevated serum IL-6 levels. These elevated IL-6 levels may have links with insulin resistance and hyperandrogenism. Metformin may have beneficial effects on the chronic low-grade inflammatory background associated with PCOS.

METHODS:

A systematic review was performed via PUBMED, EMBASE, and The Cochrane Library on PCOS studies published through November 30, 2013. Studies were selected that evaluated the effect of metformin on IL-6 levels in PCOS patients. Studies not containing adequate diagnosis information about PCOS or not excluding of other causes of hyperandrogenism were excluded.

RESULTS:

Five studies met the inclusion criteria. Of these, one study reported a significant decrease in IL-6 levels after metformin treatment in women with PCOS. Two studies reported that treatment-related reductions in IL-6 levels were significantly correlated with insulin metabolism. In the remaining two studies, plasma IL-6 levels did not change following metformin treatment.

CONCLUSIONS:

Serum IL-6 levels of PCOS patients may be influenced by metformin. Early application of metformin therapy may relieve chronic low-grade inflammation in women with PCOS. However, further investigations with larger samples are needed to better understand the effects of metformin on IL-6 levels and chronic inflammation in PCOS.

PMID:
25096410
PMCID:
PMC4149309
DOI:
10.1186/1472-6874-14-93
[Indexed for MEDLINE]
Free PMC Article
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