Format

Send to

Choose Destination
J Biotechnol. 2014 Oct 10;187:106-7. doi: 10.1016/j.jbiotec.2014.07.442. Epub 2014 Aug 2.

Complete genome sequence of the gram-negative probiotic Escherichia coli strain Nissle 1917.

Author information

1
GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: marten.reister@googlemail.com.
2
GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: Hoffmeier@genxpro.de.
3
GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: nicokrez@genxpro.de.
4
GenXPro GmbH, Altenhoeferallee 3, 60438 Frankfurt/Main, Germany. Electronic address: rotter@genxpro.de.
5
Bioinformatik, Biozentrum, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: liang@biozentrum.uni-wuerzburg.de.
6
Institut für Molekulare Infektionsbiologie, University of Wuerzburg, Josef-Schneider-Str. 2/D15, 97080 Wuerzburg, Germany. Electronic address: stefan.rund@web.de.
7
Bioinformatik, Biozentrum, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany. Electronic address: dandekar@biozentrum.uni-wuerzburg.de.
8
Department of Biological Research, Ardeypharm GmbH, Loerfeldstr. 20, 58313 Herdecke, Germany. Electronic address: sonnenborn@ardeypharm.de.
9
Institut für Molekulare Infektionsbiologie, University of Wuerzburg, Josef-Schneider-Str. 2/D15, 97080 Wuerzburg, Germany. Electronic address: t.oelschlaeger@uni-wuerzburg.de.

Abstract

Escherichia coli strain Nissle 1917 (EcN) is the active principle of a probiotic preparation (trade name Mutaflor(®)) used for the treatment of patients with intestinal diseases such as ulcerative colitis and diarrhea. It has GRAS (generally recognized as save) status and has been shown to be a therapeutically effective drug (Sonnenborn and Schulze, 2009). The complete genomic DNA sequence will help in identifying genes and their products which are essential for the strains probiotic nature. Genbank/EMBL/DDBJ accession number: CP007799 (chromosome).

KEYWORDS:

Escherichia coli Nissle 1917; Genome DNA sequence; Probiotic drug

PMID:
25093936
DOI:
10.1016/j.jbiotec.2014.07.442
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center