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J Org Chem. 2014 Sep 5;79(17):8440-6. doi: 10.1021/jo501282h. Epub 2014 Aug 15.

Rh(II)/Brønsted acid cocatalyzed intramolecular trapping of ammonium ylides with enones: diastereoselective synthesis of 2,2,3-trisubstituted indolines.

Author information

1
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, and Department of Chemistry, East China Normal University , Shanghai, 200062 People's Republic of China.

Abstract

Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh(II)/Brønsted acid cocatalytic strategy. This process allows rapid and efficient construction of N-unprotected polyfunctional 2,2,3-trisubstituted indolines in moderate to good yields with excellent diastereoselectivity.

PMID:
25093760
DOI:
10.1021/jo501282h
[Indexed for MEDLINE]

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