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Int J Pharm. 2014 Oct 20;474(1-2):91-4. doi: 10.1016/j.ijpharm.2014.07.055. Epub 2014 Aug 2.

Folate receptor targeted self-assembled chitosan-based nanoparticles for SPECT/CT imaging: demonstrating a preclinical proof of concept.

Author information

1
National "F.J.C." Research Institute for Radiobiology and Radiohygiene (NRIRR), Budapest, Hungary. Electronic address: bandi.polyak@gmail.com.
2
BBS Nanotechnology Ltd., Debrecen, Hungary.
3
Department of Nuclear Medicine, Semmelweis University, Budapest, Hungary.
4
National "F.J.C." Research Institute for Radiobiology and Radiohygiene (NRIRR), Budapest, Hungary.

Abstract

A new biocompatible, biodegradable, self-assembled chitosan-based nanoparticulate product was successfully synthesized and radiolabeled with technetium-99m, and studied as a potential new SPECT or SPECT/CT imaging agent for diagnosis of folate receptor overexpressing tumors. In the present study we examined the conditions of a preclinical application of this labeled nanosystem in early diagnosis of spontaneously diseased veterinary patient using a human SPECT/CT device. The results confirmed that the nanoparticles accumulated in tumor cells overexpressing folate receptors, contrast agent revealed higher uptake in the tumor for a long time. Preclinical trials verified that the new nanoparticles are able to detect folate-receptor-overexpressing tumors in spontaneously diseased animal models with enhanced contrast.

KEYWORDS:

(99m)Tc; Chitosan; Folate receptor; Nanomedicine; Nanoparticles; SPECT-CT

PMID:
25093694
DOI:
10.1016/j.ijpharm.2014.07.055
[Indexed for MEDLINE]

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