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Br J Cancer. 2014 Sep 23;111(7):1410-2. doi: 10.1038/bjc.2014.433. Epub 2014 Aug 5.

The risk of cancer in primary care patients with hypercalcaemia: a cohort study using electronic records.

Author information

1
University of Bristol, Centre for Academic Primary Care, School of Social and Community Medicine, Canyngne Hall, Bristol BS8 2PS, UK.
2
University of Exeter, St Luke's Campus, Exeter EX1 2LU, UK.

Abstract

BACKGROUND:

The risk of cancer with hypercalcaemia in primary care is unknown.

METHODS:

This was a cohort study using calcium results in patients aged ⩾40 years in a primary care electronic data set. Diagnoses of cancer in the following year were identified.

RESULTS:

Participants (54 267) had calcium results: 1674 (3%) were ⩾2.6 mmol l(-1). Hypercalcaemia was strongly associated with cancer, especially in males: OR 2.92, 95% CI 2.17-3.93, P=<0.001; positive predictive value (PPV) 11.5%; females: OR 1.86, 95% CI 1.39-2.50, P<0.001: PPV 4.1%.

CONCLUSIONS:

Hypercalcaemia is strongly associated with cancer in primary care, with men at most risk, despite hypercalcaemia being more common in women.

PMID:
25093495
PMCID:
PMC4183854
DOI:
10.1038/bjc.2014.433
[Indexed for MEDLINE]
Free PMC Article

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