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Cereb Cortex. 2015 Dec;25(12):4761-71. doi: 10.1093/cercor/bhu162. Epub 2014 Aug 4.

Developmental Trajectories for Visuo-Spatial Attention are Altered by Prenatal Alcohol Exposure: A Longitudinal FMRI Study.

Author information

1
Developmental Cognitive Neuroimaging Laboratory, Department of Pediatrics, Keck School of Medicine at USC/Children's Hospital of Los Angeles, Los Angeles, CA, USA.
2
Department of Neurology, University of California at Los Angeles, Los Angeles, CA, USA.
3
Department of Psychology, San Diego State University, San Diego, CA, USA.
4
Department of Nutrition, Gillings School of Global Public Health, Nutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
5
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
6
Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA.

Abstract

Functional magnetic resonance imaging (fMRI) reveals brain activation abnormalities during visuo-spatial attention and working memory among those with fetal alcohol spectrum disorders (FASD) in cross-sectional reports, but little is known about how activation changes over time during development within FASD or typically developing children. We studied 30 controls and 31 individuals with FASD over 2 years (7-14 years at first participation) with a total of 122 scans, as part of the Collaborative Initiative on Fetal Alcohol Spectrum Disorders. Despite comparable performance, there were significant group differences in visuo-spatial activation over time bilaterally in frontal, parietal, and temporal regions. Controls showed an increase in signal intensity in these multiple regions whereas FASD participants showed a decrease in brain activation. Effects were also found in 2 small independent samples from the USA, corroborating the findings from the larger group. Results suggest that the long-lasting effect of prenatal alcohol may impact the maturation of visuo-spatial attention and differentiate those with FASD from controls. Based on this first longitudinal fMRI study in FASD children, our novel findings suggest a possible neural mechanism for attention deficits common among individuals with FASD.

KEYWORDS:

development; fetal alcohol spectrum disorders; working memory

PMID:
25092900
PMCID:
PMC4635917
DOI:
10.1093/cercor/bhu162
[Indexed for MEDLINE]
Free PMC Article

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