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RETRACTED ARTICLE

See: Retraction Notice

Proteins. 2014 Aug 5. doi: 10.1002/prot.24661. [Epub ahead of print]

Retracted: Crystal structure of a Baeyer-Villiger flavin-containing monooxygenase from Staphylococcus aureus MRSA strain MU50.

Author information

1
Bioinformatics Core, Joint Center for Structural Genomics (JCSG), La Jolla, California 92037; Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, California, 92037.

Abstract

Flavin-containing Monooxygenase (FMO) catalyzed the oxygenation of broad spectrum of substrates. FMO can also serve as biocatalysts in the Baeyer-Villiger reaction in organic synthesis. Here, we report the high-resolution crystal structure of a Baeyer-Villiger Flavin-containing Monooxygenase (BVFMO) from methicillin- and vancomycin-resistant Staphylococcus aureus strain MU50. The structure of S. aureus FMO should facilitate further development of BVFMO as biocatalysts. A possible role of S. aureus FMO in methicillin and vancomycin resistance is discussed.

KEYWORDS:

Baeyer-Villiger reaction; FMO; antibiotics resistance; methicillin; vancomycin

PMID:
25092800
DOI:
10.1002/prot.24661

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