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Cancer Discov. 2014 Aug;4(8):873-5. doi: 10.1158/2159-8290.CD-14-0618.

Mouse models address key concerns regarding autophagy inhibition in cancer therapy.

Author information

1
Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania; Ravi.Amaravadi@uphs.upenn.edu jayanta.debnath@ucsf.edu.
2
Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California Ravi.Amaravadi@uphs.upenn.edu jayanta.debnath@ucsf.edu.

Abstract

With multiple clinical trials under way targeting autophagy against cancer, Yang and colleagues and Karsli-Uzunbas and colleagues address important concerns regarding autophagy inhibition in patients with cancer, using genetically engineered mouse models that more accurately represent the tumor biology found in human patients with pancreatic and lung cancers.

PMID:
25092744
PMCID:
PMC4124512
DOI:
10.1158/2159-8290.CD-14-0618
[Indexed for MEDLINE]
Free PMC Article

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