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Nat Rev Genet. 2014 Sep;15(9):577-84. doi: 10.1038/nrg3785. Epub 2014 Aug 5.

Recent advances in genomic DNA sequencing of microbial species from single cells.

Author information

1
J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, California 92037, USA.
2
1] J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, California 92037, USA. [2] School of Dentistry, Department of Periodontics, University of Washington, Seattle, Washington 98195, USA.

Abstract

The vast majority of microbial species remain uncultivated and, until recently, about half of all known bacterial phyla were identified only from their 16S ribosomal RNA gene sequence. With the advent of single-cell sequencing, genomes of uncultivated species are rapidly filling in unsequenced branches of the microbial phylogenetic tree. The wealth of new insights gained from these previously inaccessible groups is providing a deeper understanding of their basic biology, taxonomy and evolution, as well as their diverse roles in environmental ecosystems and human health.

PMID:
25091868
PMCID:
PMC4454502
DOI:
10.1038/nrg3785
[Indexed for MEDLINE]
Free PMC Article

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