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Prostaglandins Leukot Essent Fatty Acids. 2014 Oct;91(4):161-8. doi: 10.1016/j.plefa.2014.07.006. Epub 2014 Jul 17.

Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults.

Author information

1
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United States.
2
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, United States. Electronic address: aus164@psu.edu.
3
Health Diagnostic Laboratory, Inc., Richmond, VA, United States; Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, United States.
4
Department of Mathematics, Lafayette College, Easton, PA 18042, United States.

Abstract

The long-chain omega-3 polyunsaturated (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic acid (DHA), may have anti-inflammatory effects. We evaluated the dose-response effect of EPA+DHA supplementation on circulating TNF-α, IL-6, and CRP and explored associations between red blood cell (RBC) membrane PUFA content and TNF-α, IL-6, and CRP. Young adults with low fish intake (n=116) received one of five doses (0, 300, 600, 900, or 1,800 mg/d EPA+DHA) for 5 months. There were no significant effects of supplemental EPA+DHA on IL-6 or CRP; however, there was a marginal treatment effect for TNF-α (p<0.08). At baseline, higher quartiles of RBC DHA were associated with lower TNF-α (p=0.001); higher quartiles of arachidonic acid were associated with higher TNF-α (p=0.005). EPA+DHA supplementation had no dose-response effect on TNF-α, IL-6, or CRP in healthy young adults; however, associations between inflammatory markers and RBC PUFA warrant further investigation.

KEYWORDS:

C-reactive protein (CRP); Docosahexaenoic acid (DHA); Docosapentaenoic acid (DPA); Eicosapentaenoic acid (EPA); Inflammation; Omega-3

PMID:
25091379
PMCID:
PMC4156902
DOI:
10.1016/j.plefa.2014.07.006
[Indexed for MEDLINE]
Free PMC Article

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