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J Clin Virol. 2014 Oct;61(2):196-8. doi: 10.1016/j.jcv.2014.06.014. Epub 2014 Jun 23.

Human papilloma virions in the laboratory.

Author information

1
Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
2
Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA; Epidemic Intelligence Service Fellow (EIS), Centers for Disease Control and Prevention, Atlanta, GA, USA.
3
Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA.
4
Departments of Pathology and Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Electronic address: cwheeler@salud.unm.edu.

Abstract

Carcinogenic human papillomaviruses (HPV) can cause cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers. Non-carcinogenic HPVs can cause anogenital warts and recurrent respiratory papillomatosis. Currently, few research laboratories propagate, isolate or generate papilloma virions. However, there have been questions about potential exposure and risk in this setting. In this brief note, we discuss the use of wild type and laboratory-generated virions in research laboratories, potential routes of laboratory exposure, and considerations for HPV vaccination of laboratory personnel.

KEYWORDS:

HPV; HPV vaccines; Human papillomavirus; Laboratory safety

PMID:
25088765
PMCID:
PMC4277695
DOI:
10.1016/j.jcv.2014.06.014
[Indexed for MEDLINE]
Free PMC Article
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