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Int J Oral Maxillofac Surg. 2014 Nov;43(11):1313-8. doi: 10.1016/j.ijom.2014.06.016. Epub 2014 Jul 31.

Adenoid cystic carcinoma of the maxillary sinus: a clinical-pathological report of 10 years of experience from a single institution.

Author information

1
Laboratory of Oral and Maxillofacial Pathology, Department of Pathology, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
2
Department of Morphology, Institute of Biomedical Sciences, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil.
3
Department of Head and Neck Surgery, Instituto Nacional de Câncer (INCA/MS), Rio de Janeiro, RJ, Brazil.
4
Division of Pathology, Instituto Nacional de Câncer (INCA/MS), Rio de Janeiro, RJ, Brazil.
5
Laboratory of Oral and Maxillofacial Pathology, Department of Pathology, School of Dentistry, Universidade Federal de Uberlândia, Uberlândia, MG, Brazil. Electronic address: loyolaam@yahoo.com.br.

Abstract

Adenoid cystic carcinoma (ACC) is the most common malignant salivary gland tumour of the maxillary sinus. The present study describes 24 cases seen over a period of 10 years at the Brazilian National Cancer Institute. Socio-demographic, clinical, pathological, and follow-up data were retrieved from the medical files for the period 1997-2006. The mean age of the patients was 51.1 years. Twenty-one (87.5%) presented advanced tumours. The main signs and symptoms found were a tumour mass (87.5%), pain (50%), nasal obstruction (25%), and epistaxis (20.8%). Most cases (62.5%) were treated with surgery and radiation therapy. Follow-up data showed two patients (8.3%) with residual disease, local recurrences in four (16.7%) patients, and distant metastasis in five (20.8%). The overall 5- and 10-year survival rates were 72.61% and 62.11%, respectively. Maxillary sinus ACC has an aggressive but indolent behaviour, typically presenting at an advanced T stage that reflects a poor prognosis for patients.

KEYWORDS:

adenoid cystic carcinoma; head and neck cancer; maxillary sinus; salivary gland tumours; sino-nasal tract

PMID:
25088528
DOI:
10.1016/j.ijom.2014.06.016
[Indexed for MEDLINE]
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