Send to

Choose Destination
Yeast. 2015 Jan;32(1):17-27. doi: 10.1002/yea.3033. Epub 2014 Sep 23.

Saccharomyces pastorianus: genomic insights inspiring innovation for industry.

Author information

VTT Technical Research Centre of Finland, Tietotie 2, PO Box 1000, FI-02044, VTT, Espoo, Finland.


A combination of biological and non-biological factors has led to the interspecific hybrid yeast species Saccharomyces pastorianus becoming one of the world's most important industrial organisms. This yeast is used in the production of lager-style beers, the fermentation of which requires very low temperatures compared to other industrial fermentation processes. This group of organisms has benefited from both the whole-genome duplication in its ancestral lineage and the subsequent hybridization event between S. cerevisiae and S. eubayanus, resulting in strong fermentative ability. The hybrid has key traits, such as cold tolerance and good maltose- and maltotriose-utilizing ability, inherited either from the parental species or originating from genetic interactions between the parent genomes. Instability in the nascent allopolyploid hybrid genome may have contributed to rapid evolution of the yeast to tolerate conditions prevalent in the brewing environment. The recent discovery of S. eubayanus has provided new insights into the evolutionary history of S. pastorianus and may offer new opportunities for generating novel industrially-beneficial lager yeast strains.


Frohberg; S. eubayanus; Saaz; Saccharomyces pastorianus; brewing; heterosis; hybrid; lager beer

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center