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Med Sci Monit. 2014 Aug 4;20:1369-75. doi: 10.12659/MSM.890804.

Importance of metastatic lymph node ratio in non-metastatic, lymph node-invaded colon cancer: a clinical trial.

Author information

1
Department of General Surgery, Erzincan University, Erzincan, Turkey.
2
Department of General Surgery, Duzce State Hospital, Duzce, Turkey.
3
Department of Pathology, Erzincan University, Erzincan, Turkey.
4
Department of General Surgery, Yunak State Hospital, Konya, Turkey.
5
Department of General Surgery, Avicenna Hospital, Istanbul, Turkey.

Abstract

BACKGROUND:

The aim of this study was to evaluate the prognostic importance of the metastatic lymph node ratio for stage III colon cancer patients and to find a cut-off value at which the overall survival and disease-free survival change.

MATERIAL/METHODS:

Patients with pathological stage III colon cancer were retrospectively evaluated for: age; preoperative values of Crp, Cea, Ca 19-9, and Afp; pathologic situation of vascular, perineural, lymphatic, and serosal involvement; and metastatic lymph node ratio values were calculated.

RESULTS:

The study included 58 stage III colon cancer patients: 20 (34.5%) females and 38 (65.5%) males were involved in the study. Multivariate analysis was applied to the following variables to evaluate significance for overall survival and disease-free survival: age, Crp, Cea, perineural invasion, and metastatic lymph node ratio. The metastatic lymph node ratio (<0.25 or ≥0.25) is the only independent variable significant for overall and disease-free survival.

CONCLUSIONS:

Metastatic lymph node ratio is an ideal prognostic marker for stage III colon cancer patients, and 0.25 is the cut-off value for prognosis.

PMID:
25087904
PMCID:
PMC4136934
DOI:
10.12659/MSM.890804
[Indexed for MEDLINE]
Free PMC Article

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