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Stem Cell Res. 2014 Nov;13(3 Pt B):654-65. doi: 10.1016/j.scr.2014.06.005. Epub 2014 Jul 6.

Cardiac regeneration using pluripotent stem cells--progression to large animal models.

Author information

1
Department of Cardiology Westmead Hospital, Sydney, NSW, Australia; School of Medicine, University of Sydney, Sydney, NSW, Australia; Westmead Millennium Institute for Medical Research, Sydney, NSW, Australia; Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address: james.chong@sydney.edu.au.
2
Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA; Department of Pathology, University of Washington, Seattle, WA, USA; Department of Medicine/Cardiology, University of Washington, Seattle, WA, USA; Department of Bioengineering, University of Washington, Seattle, WA, USA.

Abstract

Pluripotent stem cells (PSCs) have indisputable cardiomyogenic potential and therefore have been intensively investigated as a potential cardiac regenerative therapy. Current directed differentiation protocols are able to produce high yields of cardiomyocytes from PSCs and studies in small animal models of cardiovascular disease have proven sustained engraftment and functional efficacy. Therefore, the time is ripe for cardiac regenerative therapies using PSC derivatives to be tested in large animal models that more closely resemble the hearts of humans. In this review, we discuss the results of our recent study using human embryonic stem cell derived cardiomyocytes (hESC-CM) in a non-human primate model of ischemic cardiac injury. Large scale remuscularization, electromechanical coupling and short-term arrhythmias demonstrated by our hESC-CM grafts are discussed in the context of other studies using adult stem cells for cardiac regeneration.

PMID:
25087896
PMCID:
PMC4253057
DOI:
10.1016/j.scr.2014.06.005
[Indexed for MEDLINE]
Free PMC Article

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