Preparation and self-folding of amphiphilic DNA origami

Small. 2015 Mar;11(9-10):1161-4. doi: 10.1002/smll.201401576. Epub 2014 Aug 1.

Abstract

Amphiphilic DNA origami is prepared by dressing multiple hydrophobic molecules on a rectangular single layer DNA origami, which is then folded or coupled in sandwich-like structures with two outer DNA origami layer and one inner hydrophobic molecules layer. The preference to form different kinds of structures could be tailored by rational design of DNA origami.

Keywords: DNA origami; DNA structures; hydrophobic effect; self-assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • Materials Testing
  • Microscopy, Atomic Force
  • Nanostructures / chemistry*
  • Nanotechnology
  • Nucleic Acid Conformation*
  • Surface Properties
  • Temperature

Substances

  • DNA