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Microvasc Res. 2014 Nov;96:38-45. doi: 10.1016/j.mvr.2014.07.008. Epub 2014 Jul 30.

Primary and secondary lymphatic valve development: molecular, functional and mechanical insights.

Author information

1
Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Electronic address: e.bazigou@imperial.ac.uk.
2
Department of Bioengineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Abstract

Fluid homeostasis in vertebrates critically relies on the lymphatic system forming a hierarchical network of lymphatic capillaries and collecting lymphatics, for the efficient drainage and transport of extravasated fluid back to the cardiovascular system. Blind-ended lymphatic capillaries employ specialized junctions and anchoring filaments to encourage a unidirectional flow of the interstitial fluid into the initial lymphatic vessels, whereas collecting lymphatics are responsible for the active propulsion of the lymph to the venous circulation via the combined action of lymphatic muscle cells and intraluminal valves. Here we describe recent findings on molecular and physical factors regulating the development and maturation of these two types of valves and examine their role in tissue-fluid homeostasis.

KEYWORDS:

Biomechanics; Endothelium; Interstitial fluid; Lymphatic vessel; Valve

PMID:
25086182
PMCID:
PMC4490164
DOI:
10.1016/j.mvr.2014.07.008
[Indexed for MEDLINE]
Free PMC Article

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